Pre-Prints

Peer-Reviewed Publications

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1. J. Gao, B. Nutan, D. Gargouri, N. D. Pisal, V. Do, M. Zubair, H. Alanzi, H. Wang, D. Lee, N. Joshi, A. Ullah. Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics. Advanced Therapeutics. October 2024. https://doi.org/10.1002/adtp.202400231. Link

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2. J. Joseph, H. M. Baby, J. R. Quintero, D. Kenney, Y. A. Mebratu, E. Bhatia, P. Shah, K. Swain, D. Lee, S. Kaur, X.-L. Li, J. Mwangi, O. Snapper, R. Nair, E. Agus, S. Ranganathan, J. Kage, J. Gao, J. N. Luo, A. Yu, D. Park, F. Douam, Y. Tesfaigzi, J. M. Karp, N. Joshi. Toward a Radically Simple Multi-Modal Nasal Spray for Preventing Respiratory Infections. Advanced Materials. September 2024. https://doi.org/10.1002/adma.202406348. Link  

• Press Coverage: Apple News via MarketWatch (here) (Weekend's top story), Harvard Gazette (here), Fierce Bio (here), · C&EN (here), Fast Company (here), Boston Herald (here), New Atlas (here), Microbiologist (here), Newsweek (here), Boston 25 News Video (here), Harvard Medical School (here), Investor Hangout (here), Heliox Podcast (here), The Harvard Crimson (here)

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3. Gao J, Xia Z, Gunasekar S, Jiang C, Karp JM, Joshi N. Precision drug delivery to the central nervous system using engineered nanoparticles. Nature Reviews Materials. June 2024. https://doi.org/10.1038/s41578-024-00695-w. Link

 

4. Gao J, Gunasekar S, Xia Z, Shalin K, Jiang C, Chen H, Lee D, Lee S, Pisal ND, Luo JN, Griciuc A, Karp JM, Tanzi R, and Joshi N. Gene therapy for CNS disorders: modalities, delivery and translational challenges. Nature Reviews Neuroscience. June 2024. https://doi.org/10.1038/s41583-024-00829-7. Link

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5. Li XY, Gao J, Wu C, Wang C, Zhang R, He J, Xia ZJ, Joshi N, Karp JM, and Kuai K. Precise modulation and use of reactive oxygen species for immunotherapy. Science Advances. April 2024. https://doi.org/10.1126/sciadv.adl0479. Link

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6. Banerjee A, Lee D, Jiang C, Wang R, Kutulakos ZB, Lee S, Gao J, and Joshi N. Progress and challenges in intravesical drug delivery. Expert Opinions on Drug Delivery. January 2024. https://doi.org/10.1080/17425247.2024.2307481. Link

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7. Liu H, Chen W, Wu G, Zhou J, Liu C, Tang Z, Huang X, Gao J, Xiao Y, Kong N, Joshi N, Cao Y, Abdi R, and Tao W. Glutathione-scavenging nanoparticle-mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects. Advanced Science. April 2023, 10(16). https://doi.org/10.1002/advs.202207439. Link 

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8. Gao J, Xia Z, Vohidova D, Joseph J, Luo JN, and Joshi N. Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases. Acta Pharmaceutica B. April 2023, 13(4). https://doi.org/10.1016/j.apsb.2022.07.010. Link

 

9. Gao J, Karp JM, Langer R, and Joshi N. The future of drug delivery. Chemistry of Materials. January 2023, 35(2). https://doi.org/10.1021/acs.chemmater.2c03003. Link 

 

10. Joseph J, Baby HM, Zao S, Xi L, Cheung K, Swain K, Agus E, Ranganathan S, Gao J, Luo JN, and Joshi N. Role of bioaerosol in virus transmission and material-based countermeasures. Exploration. May 2022, 2(6). https://doi.org/10.1002/EXP.20210038. Link

 

11. Aday S, Li W, Karp JM, Joshi N. An in vitro blood-brain barrier model to study the penetration of nanoparticles. Bio-protocol. 2022 Feb 20;12(4). https://doi.org/10.21769/BioProtoc.4334. Link

 

12. Gao J, Xia X, Mary HB, Joseph J, Luo JN, Joshi N. Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs. Trends in Pharmacological Sciences. March 2022;43(3). https://doi.org/10.1016/j.tips.2021.12.004. Link​

 

13. Xiao Y, Tang Z, Huang X, Joseph J, Chen W, Liu C, Zhou J, Kong N, Joshi N, Du J, Tao W. Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes. Matter. 2021 Oct 6;4(10). https://doi.org/10.1016/j.matt.2021.08.011. Link​

 

14. Zhao J, Zhang Z, Joseph J, Zhang X, Ferdows BE, Patel DN, Chen W, Banfi G, Molinaro R, Cosco D, Kong N, Joshi N, Farokhzad OC, Corbo C, Tao W. Biomaterials and nanomedicine for bone regeneration: Progress and future prospects. Exploration. 2021 Oct 30. https://doi.org/10.1002/EXP.20210011. Link

 

15. Chen W, Liu C, Ji X, Joseph J, Tang Z, Ouyang J, Xiao Y, Kong N, Joshi N, Farokhzad O, Tao W, Xie T. Stanene‐based nanosheets for β‐elemene delivery and ultrasound‐mediated combination cancer therapy. Angewandte Chemie. 2021 Mar 22;60(13). https://doi.org/10.1002/anie.202016330. Link

 

16. Jiang L, Jung S, Zhao J, Kasinath V, Ichimura T, Joseph J, Fiorina P, Liss AS, Shah K, Annabi N, Joshi N, Akama TO, Bromberg JS, Kobayashi M, Uchimura K, Abdi R. Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery. Nanotoday. 2021 Feb;36. DOI: https://doi.org/10.1016/j.nantod.2020.101045. Link

 

17. Li W, Qiu J, Li X-L, Aday S, Zhang J, Conley G, Xu J, Joseph J, Lan H, Langer R, Mannix R, Karp JM, Joshi N. BBB pathophysiology independent delivery of siRNA in traumatic brain injury. Science Advances. 2021 Jan 1;7(1). DOI: 10.1126/sciadv.abd6889. Link Press Coverage: EurekaAlert Reuters Genengnews NIH

 

18. Shanmugam T, Joshi N, Kaviratna A, Ahamad N, Bhatia E, Banerjee R. Aerosol delivery of paclitaxel-containing self-assembled nanocochleates for treating pulmonary metastasis: an approach supporting pulmonary mechanics. ACS Biomaterials Science and Engineering. 2020 Dec 21;7(1). DOI: 10.1021/acsbiomaterials.0c01126. Link

 

19. Rogers OC, Antony L, Levy O, Joshi N, Simons BW, Dalrymple SL, Rosen DM, Pickering A, Lan H, Kuang H, Ranganath S, Zheng L, Karp JM, Howard SP, Denmeade SR, Issacs JT, Brennen WN. Microparticle encapsulation of a prostate-targeted biologic for the treatment of liver metastases in a preclinical model of castration-resistant prostate cancer. Molecular Cancer Therapeutics. 2020 Sep 21;19(11). DOI: 10.1158/1535-7163.MCT-20-0227. Link

 

20. Zhao S, Karp JM, Joshi N. Toxin mediated siRNA delivery. Trends in Pharmacological Sciences. 2020 Aug;41(8): 511-13. Link

 

21. Shanmugam T, Joshi N, Ahmad N, Deshmukh A, Banerjee R. Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer. International Journal of Pharmaceutics. 2020 Aug 30;586:119482. DOI: 10.1016/j.ijpharm.2020.119482. Link

 

22. Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D’Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F. Challenges in IBD Research: Novel Technologies. Inflammatory Bowel Disease. 2019;25(2): S24-S30. Link

 

23. Balakrishnan B, Joshi N, Thorat K, Kaur S, Chandan R, Banerjee R. A tumor responsive self-healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy. Journal of Materials Chemistry B. 2019;7: 2920-25. Link

 

24. Fries CA, Lawson SD, Wang LC, Slaughter KV, Vemula PK, Dhayani A, Joshi N, Karp JM, Rickard RF, Gorantla VS, Davis MR. Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: a proof of concept study. PLoS ONE. 2019 Jan 24;14(1): e0210914. DOI: 10.1371/journal.pone.0210914. Link

 

25. Rosenblum D, Joshi N, Tao W, Karp JM, Peer D. Progress and challenges towards targeted delivery of cancer therapeutics. Nature Communications. 2019;9. DOI: 10.1038/s41467-018-03705-y. Link Press Coverage: EuerkaAlert

 

26. Joshi N. Can nanotechnology hit the spot in aerosol-based drug delivery for lung disorders? Therapeutic Delivery. 2018 Mar 2;9(4): 233-36. Link

 

27. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter K, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda O, Levy O, Gravallese EM, Aliprantis A, Ermann JE, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nature Communications. 2018;1275. DOI: 10.1038/s41467-018-03691-1. Link Press Coverage: Science Daily Fierce Biotech Journal of American Medical Association Nature Reviews Rheumatology

 

28. Joshi N. Nanotechnology enabled inhalation of bio-therapeutics for pulmonary diseases: design considerations and challenges. Current Pathobiology Reports. 2018 Oct 24;6: 225-231. Link

 

29. Tong Z, Martyn K, Yang A, Yin X, Mead BE, Joshi N, Sherman N, Langer RS, Karp JM. Towards a defined ECM and small molecule-based monolayer culture system for the expansion of mouse and human intestinal stem cells. Biomaterials. 2018 Feb;154: 60-73. Link

 

30. Joshi N, Kaur S, Banerjee R. Advances in sub-micron particle based aerosol strategies for efficient systemic delivery of therapeutic agents. Current Pharmaceutical Design. 2016;22(17): 2470-80. Link

 

31. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun;91: 140-50. Link

 

32. Sajith AM, Khader KKA, Joshi N, Reddy MN, Padusha MSA, Nagaswarupa HP, Joy MN, Bodke YD, Karuvalam RP, Banerjee R, Muralidharan A, Rajendra P. Design, synthesis and structure-activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents. European Journal of Medicinal Chemistry. 2015 Jan 7;89: 21-31. Link

 

33. Joshi N, Shirsath N, Singh A, Joshi K, Banerjee R. Endogenous lung surfactant inspired pH-responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases. Scientific Reports. 2014;4. DOI:10.1038/srep07085. Link

 

34. Balakrishnan B, Joshi N, Banerjee R. Self-crosslinked oxidized alginate/gelatin hydrogel as injectable, adhesive biomimetic scaffolds for cartilage regeneration. Acta Biomaterialia. 2014 Aug;10(8): 3650-63. Link

 

35. Joshi N, Shanmugam T, Deshmukh A, Banerjee R. Apoptotic cascade inspired lipid nanovesicles show synergism with encapsulated paclitaxel in chemoresistant colon carcinoma. Nanomedicine (London). 2014;9(12): 1789-1805. Link

 

36. Balakrishnan B, Joshi N, Banerjee R. Borate aided Schiff’s base formation yields in situ gelling hydrogels for cartilage regeneration. Journal of Materials Chemistry B. 2013;1: 5564-77. Link

 

37. Joshi N, Saha R, Shanmugam T, More P, Balakrishnan B, Banerjee R. Carboxymethyl chitosan grafted lipid vesicles: hybrid nano blanket for oral delivery of paclitaxel. Biomacromolecules. 2013;14(7): 2272-82. Link

 

38. Thakur A, Joshi N, Shanmugam T, Banerjee R. Proapoptotic miltefosine nanovesicles show synergism with paclitaxel: Implications in glioblastoma multiforme therapy. Cancer Letters. 2013 Jul 1;334(2): 274-83. Link

 

39. Joshi N, Kaviratna A, Banerjee R. Multi-trigger responsive, surface active lipid nanovesicle aerosols for improved efficacy of paclitaxel in lung cancer. Integrative Biology. 2013 Jan; 5(1): 239-48. Link

 

40. Joshi N, Shanmugam T, Kaviratna A, Banerjee R. Proapoptotic lipid nanovesicles: synergism with paclitaxel in human lung adenocarcinoma A549 cells. Journal of Controlled Release. 2011 Dec 20; 156(3): 413-20. Link